Deepak Malhotra Selected Research

marinobufagenin

1/2016	Rapamycin Attenuates Cardiac Fibrosis in Experimental Uremic Cardiomyopathy by Reducing Marinobufagenin Levels and Inhibiting Downstream Pro-Fibrotic Signaling.
4/2014	Passive immunization against marinobufagenin attenuates renal fibrosis and improves renal function in experimental renal disease.
1/2013	Gender differences in the development of uremic cardiomyopathy following partial nephrectomy: Role of progesterone.
6/2012	Monoclonal antibody against marinobufagenin reverses cardiac fibrosis in rats with chronic renal failure.
12/2009	Spironolactone attenuates experimental uremic cardiomyopathy by antagonizing marinobufagenin.
5/2009	Marinobufagenin induces increases in procollagen expression in a process involving protein kinase C and Fli-1: implications for uremic cardiomyopathy.
4/2009	The cardiotonic steroid hormone marinobufagenin induces renal fibrosis: implication of epithelial-to-mesenchymal transition.
7/2008	Effects of cardiotonic steroids on dermal collagen synthesis and wound healing.
2/2008	Partial nephrectomy as a model for uremic cardiomyopathy in the mouse.
1/2007	Marinobufagenin stimulates fibroblast collagen production and causes fibrosis in experimental uremic cardiomyopathy.

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Deepak Malhotra Research Topics

Disease

16	Fibrosis (Cirrhosis) 04/2022 - 03/2006
11	Cardiomyopathies (Cardiomyopathy) 01/2016 - 03/2006
10	Hypertension (High Blood Pressure) 07/2019 - 01/2003
10	Chronic Kidney Failure (Chronic Renal Failure) 10/2013 - 02/2002
7	Chronic Renal Insufficiency 04/2022 - 10/2013
5	Myocardial Infarction 01/2013 - 04/2009
5	Cardiomegaly (Heart Hypertrophy) 06/2012 - 01/2003
4	Inflammation (Inflammations) 04/2022 - 01/2019
4	Renal Insufficiency (Renal Failure) 12/2009 - 05/2003
3	Non-alcoholic Fatty Liver Disease 10/2020 - 01/2019
2	Colitis 06/2020 - 01/2019
2	Ischemia 01/2020 - 01/2013
2	Necrosis 01/2019 - 01/2013
2	Insulin Resistance 01/2019 - 03/2012
2	Hypernatremia 07/2018 - 01/2017
2	Glomerulonephritis 06/2013 - 12/2012
2	Hypertrophy 01/2013 - 04/2009
2	Leukemia 06/2012 - 05/2009
2	Heart Failure 05/2012 - 04/2010
2	Neoplasms (Cancer) 02/2012 - 02/2009
2	Thrombosis (Thrombus) 10/2007 - 07/2006
1	Tendinopathy (Tendonitis) 04/2022
1	Cardiovascular Diseases (Cardiovascular Disease) 03/2022
1	Pain (Aches) 01/2022
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 09/2021
1	Hyperphosphatemia 04/2021
1	Weight Loss (Weight Reduction) 06/2020
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 07/2019
1	Metabolic Diseases (Metabolic Disease) 07/2019
1	Obesity 07/2019
1	Peripheral Vascular Diseases (Peripheral Vascular Disease) 11/2017
1	Diabetes Mellitus 11/2017
1	Albuminuria 09/2017
1	Hyperglycemia 01/2017
1	Central Nervous System Diseases (CNS Diseases) 05/2015
1	Hyponatremia 11/2014
1	Proteinuria 04/2014
1	Reperfusion Injury 01/2013
1	Stroke (Strokes) 01/2013
1	Renovascular Hypertension (Goldblatt Syndrome) 01/2013
1	Rapidly progressive glomerulonephritis with pulmonary hemorrhage 12/2012
1	Vasculitis (Vasculitides) 12/2012

Drug/Important Bio-Agent (IBA)

14	Cardiac GlycosidesIBA 01/2020 - 03/2006
12	Adenosine Triphosphatases (ATPase)IBA 01/2020 - 01/2003
12	marinobufageninIBA 01/2016 - 12/2002
6	Proteins (Proteins, Gene)FDA Link 07/2019 - 01/2003
5	SaltsIBA 07/2019 - 07/2011
5	SodiumIBA 07/2018 - 12/2002
5	CollagenIBA 06/2012 - 01/2007
4	cyanoginosin LR (microcystin LR)IBA 09/2021 - 01/2019
3	CreatinineIBA 09/2017 - 04/2014
3	Transcription Factors (Transcription Factor)IBA 06/2012 - 05/2009
2	Biomarkers (Surrogate Marker)IBA 10/2020 - 09/2017
2	Alkaline PhosphataseIBA 10/2020 - 01/2019
2	Dextran SulfateIBA 06/2020 - 01/2019
2	PotassiumIBA 07/2018 - 01/2017
2	Deamino Arginine Vasopressin (Desmopressin)FDA LinkGeneric 11/2014 - 07/2006
2	Monoclonal AntibodiesIBA 04/2014 - 06/2012
2	digoxin antibodies Fab fragments (Fabad)IBA 04/2014 - 06/2012
2	Spironolactone (Aldactone)FDA LinkGeneric 01/2013 - 12/2009
2	Digoxin (Digitek)FDA LinkGeneric 06/2012 - 07/2008
2	bufadienolideIBA 06/2012 - 09/2011
2	Hormones (Hormone)IBA 04/2009 - 02/2009
1	Aryldialkylphosphatase (Paraoxonase)IBA 04/2022
1	AntioxidantsIBA 03/2022
1	Opioid Analgesics (Opioids)IBA 01/2022
1	Uremic ToxinsIBA 04/2021
1	Alanine Transaminase (SGPT)IBA 10/2020
1	Plasminogen Activator Inhibitor 1IBA 06/2020
1	CytokinesIBA 06/2020
1	Natriuretic AgentsIBA 01/2020
1	CEACAM1 ProteinIBA 01/2019
1	LigandsIBA 08/2018
1	Urea (Carbamide)FDA LinkGeneric 07/2018
1	Angiotensin Receptor AntagonistsIBA 11/2017
1	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 11/2017
1	Cystatin CIBA 09/2017
1	Glucose (Dextrose)FDA LinkGeneric 01/2017
1	Sirolimus (Rapamycin)FDA Link 01/2016
1	Vasopressins (Vasopressin)IBA 11/2014
1	Immunoglobulin G (IgG)IBA 04/2014
1	Fast GreenIBA 04/2014
1	ProteomeIBA 10/2013
1	Complement System Proteins (Complement)IBA 06/2013
1	CanrenoneIBA 01/2013
1	Mineralocorticoid Receptor AntagonistsIBA 01/2013
1	Progesterone FDA LinkGeneric 01/2013
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2013
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2013
1	Hydralazine (Apresoline)FDA LinkGeneric 12/2012
1	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 12/2012

Therapy/Procedure

9	Nephrectomy 04/2014 - 01/2003
5	Therapeutics 04/2022 - 10/2007
3	Renal Dialysis (Hemodialysis) 05/2015 - 07/2006
3	Ligation 01/2013 - 04/2009
1	Injections 04/2022
1	Conservative Treatment 04/2022
1	Analgesia 01/2022
1	Kidney Transplantation 01/2020
1	Surgical Instruments (Clip) 01/2013